At a Glance
- Tasks: Lead innovative research in computational and systems biology to tackle cancer therapy challenges.
- Company: Adelaide University, a hub for cutting-edge cancer research and collaboration.
- Benefits: Competitive salary, 17% superannuation, and opportunities for professional growth.
- Other info: Join a diverse team committed to inclusion and lifelong learning.
- Why this job: Make a real impact in cancer research while developing your skills in a supportive environment.
- Qualifications: PhD in relevant fields and experience in computational modelling and biological data analysis.
The predicted salary is between 111384 - 111384 $ per year.
Based in the Faculty of Health, SAiGENCI. 12 Months Fixed Term contract (1 FTE) extendable for a further 2 years. Level A - $103,962 - $111,384 per annum plus an employer contribution of 17% superannuation applies.
We are seeking a highly motivated Postdoctoral Research Fellow in computational and systems biology to lead the mechanistic modelling stream of a new research program on adaptive resistance to targeted cancer therapy. The successful candidate will develop and calibrate mechanism models that link time-resolved signalling adaptation to drug exposure (PK), target and pathway modulation (PD), and tumour dynamics, with EGFR- and KRAS-driven non‑small cell lung cancer as the flagship setting. A complementary stream applying machine learning to pharmacogenomic and patient‑derived datasets to build deployable predictive biomarker panels offers additional scope.
The Integrative Network Modelling Group within the Computational Systems Oncology program at SAiGENCI sits at the intersection of mathematics, computation, and cancer biology. We develop mechanistic, predictive models of cellular decision‑making to address both fundamental and translational challenges in oncology, including drug resistance, pathway rewiring, and the discovery of new therapeutic vulnerabilities. Our approach is deliberately cancer‑agnostic, focusing on principles that generalize across various tumour types while exploring the governing and design principles that dictate complex signalling behaviour.
A defining feature of our group is the tight integration of dynamic network modelling with experimental and clinical insight, enabling us to move beyond mere description and toward robust, actionable prediction. If you are a talented systems biologist driven by both curiosity and discipline, we want you on our team!
The role is ideal for candidates with a strong background in applied mathematics, systems biology, and computational biology, as well as practical experience in dynamic model development and the analysis of large‑scale biological data, who are excited to apply rigorous computational modelling approaches to real biological and biomedical problems. Support and mentorship will be provided to enable strong quantitative researchers to deepen their biological and translational expertise over time.
To thrive in this role, you will likely have the following skills and experience:
- PhD (awarded, or submitted and under examination) in Computational Biology, Systems Biology, Applied Mathematics, Biomedical Engineering, or a closely related quantitative discipline, with demonstrated application to biological systems.
- Expertise in developing and applying ODE-based models of intracellular signalling, including model formulation, calibration, parameter identifiability, uncertainty and sensitivity analysis.
- Experience with agent‑based or logic‑based approaches is advantageous.
- Demonstrated ability to translate biological and clinical questions into practical computational frameworks, bridge wet- and dry‑lab environments, and design model‑informed experiments in collaboration with biologists and clinicians.
- Proven ability to translate complex computational outputs into meaningful biological and clinical insights.
We are committed to fostering a culture of inclusion where diversity is celebrated and everyone feels respected and valued. Adelaide University is an equal opportunity employer, committed to creating a safe, inclusive, and equitable workplace where everyone can thrive. We strongly encourage applications from Aboriginal and Torres Strait Islander peoples, people with disability, and people of all ages, genders, cultural backgrounds, sexual orientations, and gender identities. We are committed to supporting flexible working arrangements and providing reasonable adjustments throughout the recruitment process.
Submit your application by 11:30pm Sunday 11 October 2026. The University reserves the right to close this advertisement before the closing date if a suitable candidate is identified.
For further information about this opportunity, please contact (quoting reference number 493454): +61 8 8302 1700 | careers.adelaideuniversity@adelaide.edu.au
Postdoctoral Research Fellow in Adelaide employer: Adelaide University
At Adelaide University, we pride ourselves on being an exceptional employer that fosters a vibrant and inclusive work culture. As a Senior Manager in Biological Services, you will not only lead a dedicated team but also have access to professional development opportunities and a supportive environment that values innovation and collaboration. With a commitment to excellence and a focus on creating a better tomorrow, you'll be part of a community that inspires future change-makers while enjoying competitive benefits and a strong emphasis on work-life balance.
